All projects

Cancer immunology · Kron Lab

TET2 Inhibition Cancer Research

I evaluated small-molecule TET2 inhibition in CT-26 cell cultures as a possible way to address adaptive resistance to radiation therapy.

Role

Independent researcher

Lab

Kron Lab · UChicago

Time

300+ wetlab hours

Recognition

2nd of 36 presenters

Samuel Frausto's TET2 inhibition research poster
Research poster presented at the UIUC cancer research symposium
Download research poster (.pptx)
Study structureCT-26 · TET2 · Radiation resistance
01 · MODEL

CT-26 cell culture

I maintained the cancer-cell model used to test the research question.

02 · INTERVENTION

Small-molecule TET2 inhibition

I evaluated the drug strategy against radiation-resistant cells.

03 · QUESTION

Adaptive resistance

Could inhibiting TET2 help overcome the cells' adaptive response to radiation?

The research

A focused test of one therapeutic strategy.

Radiation-resistant cancer cells can adapt to treatment. My project tested whether small-molecule inhibition of TET2 could be a useful strategy for addressing that resistance.

I completed more than 300 hours of wetlab work in the University of Chicago's Kron Lab. I handled the cell-culture work, evaluated the treatment approach, analyzed the study data, and prepared the project for presentation.

My work

From cell culture to faculty review.

01 · Cell culture

I cultured CT-26 cell lines for the radiation-resistance study.

02 · Evaluation

I tested the effects of small-molecule TET2 inhibition on the study model.

03 · Analysis

I analyzed the experimental data and converted the work into a clear research presentation.

04 · Presentation

I presented the project at the UIUC cancer research symposium to faculty from universities across Illinois.

Outcome

The project placed second out of 36 presenters at the UIUC symposium and inspired a subsequent grant-winning study by a fellow lab member.

UIUC CANCER RESEARCH SYMPOSIUM · 2ND PLACE